GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs10935120 | 1 | rs7630874 | chr3:134293291 | ANAPC13 | chr3:134196547-134204865:- | -0.5 | -7.96 | 1.97E-14 | Height |
| BLCA | cis | rs10935120 | 1 | rs7630874 | chr3:134293291 | CEP63 | chr3:134204575-134293852:+ | -0.24 | -4.12 | 4.57E-5 | Height |
| BLCA | cis | rs9815354 | 1 | rs7631057 | chr3:41817951 | ULK4 | chr3:41288091-42003660:- | 0.65 | 9.85 | 1.54E-20 | Diastolic blood pressure |
| BLCA | cis | rs9815354 | 1 | rs7632387 | chr3:41853161 | ULK4 | chr3:41288091-42003660:- | 0.64 | 9.72 | 4.04E-20 | Diastolic blood pressure |
| BLCA | cis | rs1401999 | 1 | rs7632670 | chr3:183713877 | ABCC5 | chr3:183637726-183735727:- | -0.2 | -3.9 | 0.000113 | Anterior chamber depth |
| BLCA | cis | rs7611238 | 1 | rs7633265 | chr3:195048814 | C3orf21 | chr3:194789015-194991895:- | 0.29 | 5.71 | 2.32E-8 | Body mass index |
| BLCA | cis | rs7611238 | 1 | rs7634345 | chr3:195073403 | C3orf21 | chr3:194789015-194991895:- | 0.28 | 5.33 | 1.66E-7 | Body mass index |
| BLCA | cis | rs9876781 | 1 | rs7636044 | chr3:48484560 | TREX1 | chr3:48501186-48509043:+ | -0.19 | -3.82 | 0.000153 | Longevity |
| BLCA | cis | rs10935120 | 1 | rs7637227 | chr3:134244155 | ANAPC13 | chr3:134196547-134204865:- | 0.49 | 7.75 | 8.37E-14 | Height |
| BLCA | cis | rs9910950 | 1 | rs76375367 | chr17:64138784 | AXIN2 | chr17:63524685-63637183:- | 0.54 | 4.63 | 4.91E-6 | Presence of antiphospholipid antibodies |
| BLCA | cis | rs6951245 | 1 | rs76388414 | chr7:1100694 | ZFAND2A | chr7:1192544-1199855:- | -0.38 | -4.45 | 1.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs344081 | 1 | rs7639514 | chr3:156576067 | LEKR1 | chr3:156544076-156763918:+ | -0.45 | -6.37 | 5.45E-10 | Bone mineral density |
| BLCA | cis | rs6764050 | 1 | rs7640320 | chr3:187430530 | ST6GAL1 | chr3:186648516-186796339:+ | -0.41 | -4.27 | 2.51E-5 | Response to citalopram treatment |
| BLCA | cis | rs7714584 | 1 | rs76433514 | chr5:150306532 | LOC134466 | chr5:150310000-150326146:- | 0.55 | 6.87 | 2.64E-11 | Crohn's disease |
| BLCA | cis | rs10935120 | 1 | rs7645295 | chr3:134307734 | ANAPC13 | chr3:134196547-134204865:- | 0.48 | 7.59 | 2.51E-13 | Height |